Chemical synthesis of ω- hydroxyderivatives of plant fatty acid substrates.
Abstract
A common synthetic procedure for the synthesis of (9Z,12Z)-18-hydroxy-9,12- octadecadienoic acid (18-HODE) and (9Z,12Z,15Z)-18-hydroxy-9,12,15- octadecatrienoic acid (18-HOTrE) – analogues of substrates of plant lipids oxygenation was developed. The synthetic route is based on formation of polyacetylenic precursors followed by stereoselective reduction of the triple bonds on Lindlar’s catalyst.
About the Authors
N. V. Groza
M.V. Lomonosov Moscow State University of Fine Chemical Technologies, 86, Vernadskogo pr., Moscow 119571
Russian Federation
Russian Federation
I. V. Ivanov
M.V. Lomonosov Moscow State University of Fine Chemical Technologies, 86, Vernadskogo pr., Moscow 119571
Russian Federation
Russian Federation
A. B. Golovanov
M.V. Lomonosov Moscow State University of Fine Chemical Technologies, 86, Vernadskogo pr., Moscow 119571
Russian Federation
Russian Federation
G. I. Myagkova
M.V. Lomonosov Moscow State University of Fine Chemical Technologies, 86, Vernadskogo pr., Moscow 119571
Russian Federation
Russian Federation
References
1. I.Stenzel, B.Hause, O.Miersch, T.Kurz, H.Maucher, H.Weichert, J.Ziegler, I.Feussner,
2. C.Wasternack. //Plant Molecular Biology. – 2003. – Vol.51. – P.895-911.
3. I.Feussner, C.Wasternack. //Annu. Rev. Plant Biol. – 2002. – Vol.53. – P.275-297.
4. И.В. Иванов, Н.В.Гроза, Е.Е.Мнасина, Г.И. Мягкова. //Биоорган. Химия. – 1995. –
5. Т.21, № 10. – С.802-805.
6. И.В. Иванов, Н.В.Гроза, Кюн Х., Г.И. Мягкова. //Биоорган. химия. – 1998. – Т.24,
7. № 6. – С.454-457.
8. H.Sprecher. //Progr. Chem. Fats Other Lipids. – 1978. – Vol.15. – P.219-254.
9. M.A. Lapitskaya, L.L.Vasiljeva, K.K.Pivnitsky. //Synthesis. – 1993. – P.65-66.
Review
For citations:
Groza N.V., Ivanov I.V., Golovanov A.B., Myagkova G.I. Chemical synthesis of ω- hydroxyderivatives of plant fatty acid substrates. Fine Chemical Technologies. 2006;1(4):29-32. (In Russ.)
Views: 276
Email this article 
