Preview

Fine Chemical Technologies

Advanced search

Preparation of multilayer capsules based on chitosan and alginic acid salts for phospholipid micelles encapsulation

Abstract

A method of obtaining capsules with coats based on chitosan and alginic acid calcium or barium salts containing phosphatidylcholine micelles is described. These capsules can be used to create oral drug delivery systems, means of vaccination, etc.

About the Authors

O. V. Manaenkov
Тверской государственный технический университет
Russian Federation


A. I. Sidorov
Тверской государственный технический университет
Russian Federation


V. P. Molchanov
Тверской государственный технический университет
Russian Federation


References

1. Сливкин, А. И. Полиурониды. Структура, свойства, применение (обзор) / А. И. Сливкин // Вестник ВГУ. Серия химия, биология. - 2000. - С. 30-46.

2. Усов, А. И. Альгиновые кислоты и альгинаты: методы анализа, определения состава и установления строения / А. И. Усов // Успехи химии. - 1999. - Т. 68, № 11. - С. 1051-1061.

3. Biological interactions between polysaccharides and divalent cations: the egg - box model / G. T. Grant [et al.] // FEBS Lett. - 2003. - № 32 - Р. 195-198.

4. Гальбрайх, Л. С. Хитин и хитозан: строение, свойства, применение / Л. С. Гальбрайх // Соросовский образовательный журнал. - 2001. - Т. 7, № 1. - С. 51-56.

5. Хитин и хитозан: получение, свойства и применение / Под ред. К. Г. Скрябина, Г. А. Вихоревой, В. П. Варламова. - М. : Наука, 2002. - 315 с

6. Immunogenicity of orally-delivered lipid-formulated BCG vaccines and protection against Mycobacterium tuberculosis infection / J. Vipond [et al.] // Microbes Infect. - 2008. - № 10. - P. 1577-1581.

7. Nanotechnology in vaccine delivery / L. J. Peek [et al.] // Adv. Drug Deliv. Rev. - 2008. - Vol. 60, № 8. - P. 915-928.

8. Oral vaccination with liposome-encapsulated recombinant fusion peptide of urease B epitope and cholera toxin B subunit affords prophylactic and therapeutic effects against H. pylori infection in BALB/c mice / W. Zhao [et al.] // Vaccine. - 2007. - Vol. 25, № 44. - P. 7664-7673.

9. Oral vaccination with modified vaccinia virus Ankara attached covalently to TMPEG-modified cationic liposomes overcomes pre-existing poxvirus immunity from recombinant vaccinia immunization / T. Naito [et al.] // J. Gen. Virol. - 2007. - Vol. 88, № 1. - P. 61-70.

10. Preparation of double liposomes and their efficiency as an oral vaccine carrier / S. Ogue [et al.] // Biol. Pharm. Bull. - 2006. - Vol. 29, № 6. - P. 1223-1228.

11. Particulate systems as adjuvants and carriers for peptide and protein antigens / M. T. Liang [et al.] // Curr. Drug Deliv. - 2006. - Vol. 3, № 4. - P. 379-388.

12. Lipoinsulin encapsulated alginate-chitosan capsules: intestinal delivery in diabetic rats / M. Ramadas [et al.] // J. Microencapsul. - 2000. - Vol. 17, № 4. - P. 405-411.

13. Oral colon-specific drug delivery for bee venom peptide: development of a coated calcium alginate gel beads-entrapped liposome / L. Xing [et al.] // J. Control Release. - 2003. - Vol. 93, № 3. - P. 293-300.

14. Preparation and characterization of liposomes-in-alginate (LIA) for protein delivery system // Colloids Surf. B. Biointerfaces. - 2006. - Vol. 47, № 2. - P. 205-210.

15. Фармакология некрахмальных полисахаридов / Ю.С. Хотимченко [и др.] // Вестник ДВО РАН. - 2005. - № 1. - С. 72-82.

16. Hydrogel-based encapsulation of biological, functional tissue: fundamentals, technologies and applications / H. Zimmermann [et al.] // Appl. Phys. - 2007. - Vol. A 89. - P. 909-922.

17. Lipid-alginate interactions render changes in phospholipid bilayer permeability / S. Cohen [et al.] // Biochim. Biophys. Acta. - 1991. - Vol. 1063, № 1. - P. 95-102.


Review

For citations:


Manaenkov O.V., Sidorov A.I., Molchanov V.P. Preparation of multilayer capsules based on chitosan and alginic acid salts for phospholipid micelles encapsulation. Fine Chemical Technologies. 2010;5(2):76-81. (In Russ.)

Views: 414


ISSN 2410-6593 (Print)
ISSN 2686-7575 (Online)